Gluten-Related Neurological Symptoms and Conditions
There's no question that gluten can affect your neurological system: people with both celiac disease and non-celiac gluten sensitivity report symptoms that range from headaches and brain fog to peripheral neuropathy (tingling in your extremities). May 24, · In NCGS, gluten-triggered inflammation in the gut can instigate inflammation in the brain, referred to as neuroinflammation. Neuroinflammation has been found to play a central, triggering role in brain-related disease. In NCGS, there is a series of steps in the process that ultimately culminates in neuroinflammation and brain ctcwd.coms:
Several years ago, parents of a lovely nine-year-old girl, Karen, brought her to see me because she had poor memory. They indicated that she had difficulty in thinking and focusing, and because of these issues she was falling further and further behind in her glutsn work. Interestingly, they stated that at times she was fine, while clearly at other times her brain function seemed to be different.
They indicated that she had difficulty keeping her thoughts together and that she became profoundly frustrated when this would occur. Because of her significant doss with academic performance, her parents elected to home school her. Her academic testing revealed that she was functioning at or below a third grade level in a variety of areas, including math skills, reading fluency, story recall and overall academic skills.
Fortunately, she had no significant medical problems in her past and her overall physical, as well as neurological examinations were entirely normal.
Routine, typical blood studies were unrevealing, so I was left to reconsider her history to see odes there were whar clues as to what might be causing this child's problems. What caught my attention was the interesting fact that her problems were not constant, indicating that basically her brain was intact but something seemed to be detrimentally influencing her from time to time, causing her to have these significant issues with respect to how her brain functioned. In considering what factors change day to day in terms of someone's exposure, certainly diet is how to use an etrex gps the top of the list.
Recognizing that gluten sensitivity a protein ahat in wheat, barley and rye is extremely common, I decided to perform a simple blood test to determine if glutne child was gluten barin.
When the laboratory studies were completed, we were surprised to learn that she was profoundly sensitive to gluten. So at that point I instructed her parents dose put her on a gluten-free diet. While they considered this diet uour be challenging, eliminating all wheat, barley and rye from her diet, nevertheless they complied. Over the next two weeks, her parents observed a remarkable change in her cognitive function.
Karen suddenly was able to focus much more readily on her school work and indicated to her parents that wgat suddenly noticed she was thinking much more clearly.
Her parents maintained her on a gluten-free diet and over the next several months continued to notice further improvements in her school work. At the end of the school year, she was tested and her grade level equivalent for math calculation skills was 5. Prior to removing gluten from her diet, academics, especially math, were difficult. As you can see, she is now soaring in math.
Based upon this test, entering the fourth grade next year, she would be at the top of her class. The teacher indicated that if she skipped fourth grade and went to fifth grade, she would be in the middle of her class. What an accomplishment! Louis Pasteur stated, "Chance favors the prepared mind. Because of this experience, I became deeply involved in research exploring the effects of gluten sensitivity on the brain.
I learned that gluten sensitivity, glhten as celiac disease, is actually an extremely common human affliction. In fact, it has been described as "one of the most common human diseases. This is an astounding statistic glyten you consider that at the time of this writing, there are approximately , Americans. That means, about 3 million Americans are gluten sensitive. When you consider the population from birth to age five years is 23 million children, that means that approximatelyof these children are gluten sensitive.
It seems astounding that a disease that is so common, is nevertheless, fairly obscure. Despite the fact that it was originally described inwe still don't hear much about it. Standard medical text books typically describe celiac disease gluten sensitivity as being primarily a gastrointestinal problem.
I recall in medical school being taught that celiac disease was characterized by abdominal pain, abdominal distention with bloating and gas, decreased appetite, diarrhea, nausea, unexplained weight loss and growth delay in children.
Newer research indicates that celiac brian can have a profound effect on the nervous system. Maios Hadjivassiliou of whst United Kingdom, braln recognized world authority on gluten sensitivity, has reported in the journal, The Lancetthat "gluten sensitivity can be primarily and at times, exclusively a neurological disease. Hadjivassiliou indicates that the antibodies that a person has when they are gluten sensitive can be directly and uniquely toxic to the brain.
Since his original investigations inthe recognition that gluten sensitivity can lead how to claim government super co contribution disorders of brain function has led to a virtual explosion of scientific papers describing this relationship.
As authors in a recent issue of the journal, Pediatricsstated in their research, "This study suggests that the variability of neurologic disorders that occur in celiac brian is broader than previously reported and includes softer and more yohr neurologic disorders including chronic headache, developmental delay, hypotonia and learning disorders or ADHD.
The link between gluten sensitivity and problems with brain function, including learning disabilities, difficulty staying on task and even memory dysfunction, is actually not that difficult to understand. Gluten sensitivity is caused by elevated levels of antibodies against a component of fluten, gliadin. This antibody anti-gliadin antibody combines with gliadin when a person is exposed to any gluten containing food like wheat, barley or rye.
Testing for the antibody can be performed in any doctor's office. When the antibody combines brrain this gkuten, specific genes are turned on in a special type of immune cell in the body. When these genes are turned on, inflammatory chemicals are created called cytokines, which are directly detrimental to brain function.
In fact, elevated what colour tiles go with walnut kitchen are seen in such devastating conditions as Alzheimer's disease, Parkinson's disease, multiple sclerosis and even autism. Basically, the brain does not like inflammation and responds quite negatively to the presence of cytokines.
Another problem with anti-gliadin antibody is that it can directly combine with bgain proteins found in the brain. Specific brain proteins can look like the gliadin protein found in gluten-containing foods and the anti-gliadin antibody just can't tell the difference.
This direct role of anti-gliadin antibody in combining with specific proteins in the brain, has been described for decades and again leads to the formation of cytokines, the chemical mediators of inflammation. This is an example of turning on genes that ultimately function in a negative way in relation to brain health and function. US Edition U. Coronavirus News U. Politics Joe Biden Congress Extremism.
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Gluten stimulates zonulin. Zonulin is a substance that regulates the permeability of the lining of the brain and gut through activation of epidermal growth factor receptors and protease-activated receptors. It is through this mechanism that gluten contributes to leakiness of the blood-brain barrier. To simplify, gluten upregulates zonulin. Jul 04, · Gluten is a foreign protein to human physiology, and is the cornerstone of leaky brain-causing inflammation. Science has made some amazing discoveries about the blood brain barrier in recent years, most importantly that it can become just as permeable as our gut lining. Dec 20, · Gluten induces this cornerstone of brain degeneration: inflammation. It causes leakiness of the blood-brain barrier.” The blood-brain barrier is a network of endothelial cells that prevents.
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There's no question that gluten can affect your neurological system: people with both celiac disease and non-celiac gluten sensitivity report symptoms that range from headaches and brain fog to peripheral neuropathy tingling in your extremities.
Neurological illnesses such as epilepsy, depression, and anxiety also are common in those who react to gluten. In addition, a serious autoimmune condition called gluten ataxia affects a small number of people. There are hints that conditions such as schizophrenia and bipolar disorder also may be affected by gluten intake in a few individuals. However, it's not yet clear from the research who might be affected, while it does show a gluten-free diet can help some people.
Research shows that people with celiac disease suffer from much higher-than-average rates of depression and anxiety. People who test negative for celiac disease but who have been diagnosed with gluten sensitivity also report higher levels of depression and anxiety, although the links between the conditions are less clear because they haven't been studied thoroughly.
It's not clear why gluten ingestion leads to these two neurological conditions. Researchers have speculated that gluten-related intestinal damage might lead to nutritional deficiencies that cause depression and anxiety in people with celiac disease deficits in certain B vitamins can cause some symptoms.
However, that wouldn't explain why people with non-celiac gluten sensitivity who don't get intestinal damage from gluten also suffer from those two mental conditions. Some gluten sensitivity experts—notably, New Zealand pediatrician Dr.
Rodney Ford—have hypothesized that gluten affects your brain directly to cause these conditions, but this theory hasn't been proven. Regardless, you're far from alone if you experience depression and anxiety from gluten. Many people with celiac disease and gluten sensitivity can tell quickly when they've accidentally been glutened.
Their brains cloud up and they feel less effective, even stupid and clumsy. This phenomenon, known as brain fog , has received little study, but it's another extremely common symptom for both celiac and gluten sensitivity.
Attention deficit hyperactivity disorder ADHD is another frequent complaint, in both adults and children. People who have kids with gluten problems can attest that school performance is much better when their diets are free of gluten! Migraines are commonly mentioned as both celiac disease symptoms and gluten sensitivity symptoms.
Up to one-third of people with these conditions report experiencing migraine headache pain. Epilepsy results when neurons in the brain fire incorrectly, leading to seizures and potentially even unconsciousness. Celiac disease also has been associated with a rare constellation of epilepsy and bilateral occipital calcifications. Vertigo —or a sensation of dizziness and spinning—occurs due to a malfunction in the balance system housed in your inner ear. There are two studies potentially linking Meniere's disease a form of vertigo with celiac disease, but anecdotal complaints of vertigo are frequent among people with celiac disease.
People who have celiac disease or gluten sensitivity have high levels of peripheral neuropathy , which causes a tingling or "pins-and-needles" sensation in your feet and fingers. The sensation stems from damage to the nerves in your extremities, and the condition may improve once you go gluten-free.
There have been many reports suggesting gluten could be implicated in two very serious psychiatric conditions—bipolar disorder and schizophrenia. In bipolar disorder, there are a few studies that indicate people with celiac or gluten sensitivity may have higher rates of the mental condition.
There's also an intriguing study that looked at levels of antibodies to gluten in the bloodstream of people with bipolar disorder and found high levels in those in the midst of a manic episode. In schizophrenia, meanwhile, there have been decades of speculation that eliminating bread a major source of gluten from the diet of people with schizophrenia can help.
Research has shown a gluten-free diet can have benefits to individuals with schizophrenia, but more study is needed. When gluten consumption causes your body to attack its own tissues, you have a gluten-induced autoimmune condition.
The three of these conditions are celiac disease damage to the small intestine , dermatitis herpetiformis damage to the skin , and gluten ataxia damage to the brain. When you have gluten ataxia , your immune system attacks your cerebellum, the part of your brain responsible for coordination. In many cases, the damage is irreversible, although a strict gluten-free diet can halt the progression of the condition.
Gluten ataxia can impact the nervous system. The number of people who have it is thought to be very small. However, many more people with celiac or gluten sensitivity have symptoms similar to those seen in gluten ataxia.
There's no question that celiac disease and gluten sensitivity can lead to a wide array of neurological problems and conditions. However, in many cases, you can reduce or even resolve your gluten-related neurological symptoms by following a strict gluten-free diet. Following a gluten-free diet can be challenging. We're here to help. Sign up and receive our free recipe guide for delicious gluten-free meals! Mood disorders and gluten: it's not all in your mind!
Celiac Disease Foundation. Updated Ford RP. The gluten syndrome: a neurological disease. Med Hypotheses. Yelland GW. Gluten-induced cognitive impairment "brain fog" in coeliac disease. J Gastroenterol Hepatol. Niederhofer H. National Headache Foundation. Headache frequently accompanies celiac disease and other digestive disorders.
Updated June 15, Gluten sensitivity and epilepsy: a systematic review. J Neurol. Acta Otorhinolaryngol Ital. Neurological manifestations of neuropathy and ataxia in celiac disease: a systematic review. Celiac and non-celiac gluten sensitivity: a review on the association with schizophrenia and mood disorders. Auto Immun Highlights. Use of a gluten-free diet in schizophrenia: a systematic review.
Adv Nutr. Clinical and diagnostic aspects of gluten related disorders. World J Clin Cases. Beyond Celiac. Gluten ataxia and celiac disease. Your Privacy Rights. To change or withdraw your consent choices for VerywellHealth.
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